Amino Acid Derivatives

Amino Acid Derivatives are bioactive molecules formed through chemical modifications or metabolic transformations of amino acids. They are widely present in living organisms and play crucial roles in physiological, psychological, and athletic performance.
The functions of these derivatives primarily include enhancing energy supply, regulating neurotransmitters, promoting fat metabolism, and reducing muscle damage. For example, creatine can increase muscle strength, enhance ATP resynthesis, and improve short-duration high-intensity exercise performance; tyrosine, as a precursor of dopamine and norepinephrine, helps enhance cognitive function and improve mood, particularly in sleep deprivation conditions, exhibiting anti-fatigue effects; carnitine facilitates fatty acid oxidation in the heart and skeletal muscles, improving endurance performance; HMB (β-hydroxy-β-methylbutyrate) reduces muscle breakdown and promotes muscle mass gain; while taurine exhibits antioxidant and antihypertensive properties and reduces oxidative stress induced by exercise.
Metabolic abnormalities or improper supplementation of amino acid derivatives may be associated with various diseases. For instance, tyrosine metabolism disorders can disrupt neurotransmitter balance, potentially leading to depression or stress-related disorders; elevated ADMA (asymmetric dimethylarginine) levels can inhibit nitric oxide synthesis, increasing the risk of cardiovascular diseases; carnitine deficiency is linked to certain genetic muscle disorders, impairing fat metabolism and energy production. Additionally, HMB may help slow muscle loss under specific conditions, while taurine intake is associated with improved cardiovascular health. Although some of the effects of these derivatives remain debated, they hold significant potential applications in sports nutrition, neurological regulation, and metabolic health.

References:

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-807. [Content Brief]

Amino Acid Derivatives Chemical (1)

Amino Acid Derivatives Related Products (1579):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-Y1636

Fmoc-Arg(Pbf)-OH		99.97%
Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis).

HY-N0473A

L-Tyrosine disodium salt		99.79%
L-Tyrosine (disodium) is a tyrosine derivative.

HY-W007408

tert-Butyl 2-aminoacetate		99.64%
tert-Butyl 2-aminoacetate is a Glycine (HY-Y0966) derivative.

HY-W048205

N6-Diazo-L-Fmoc-lysine		99.84%
N6-Diazo-L-Fmoc-lysine is an active compand and can be used in a variety of chemical studies. N6-Diazo-L-Fmoc-lysine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151642A

3-Azido-D-alanine hydrochloride		99.94%
3-Azido-D-alanine hydrochloride is an azido-modified D-alanine (HY-41700) hydrochloride. 3-Azido-D-alanine hydrochloride can be used in the research of click chemistry labeling. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-W097122

Fmoc-Gly-Gly-Gly-OH		98.49%
Fmoc-Gly-Gly-Gly-OH is a tripeptide that can be used in peptide synthesis.

HY-W769077

N-Valerylglycine-¹³C₂,¹⁵N
N-Valerylglycine-¹³C₂,¹⁵N is the ¹³C- and ¹⁵N-labeled N-Valerylglycine (HY-W141934). N-Valerylglycine is a Glycine (HY-Y0966) derivative.

HY-W750256

Alitame-d₃
Alitame-d₃ is the deuterium labeled Alitame (HY-129847). Alitame is a high-intensity sweetener formed from the?amino acids?L-aspartic acid and D-alanine, and an amine derived from thietane.

HY-Y1250

Fmoc-Gly-OH		99.98%
Fmoc-Gly-OH (Fmoc glycine) is a Fmoc-protected glycine derivative, can be used for the synthesis of compounds.

HY-W040124

DL-Propargylglycine		≥98.0%
DL-Propargylglycine is a Glycine (HY-Y0966) derivative. DL-Propargylglycine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-Y1169

Fmoc-Asp(OtBu)-OH		99.85%
Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is an aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis.

HY-W009204

Fmoc-Ala-OH		99.92%
Fmoc-Ala-OH is an alanine derivative.

HY-59291

Levacetylleucine	Chemical	≥98.0%
Levacetylleucine (N-acetyl-L-leucine), an orally bioavailable and brain-penetrant compound, is an acetylated derivative of amino acid Leucine. Levacetylleucine is the active form of N-acetyl-leucine (NAL). Levacetylleucine attenuates neuronal death and neuroinflammation in the cortical tissue of mice. Levacetylleucine also potentially improves ameliorates lysosomal and metabolic dysfunction. Levacetylleucine improves compensation of postural symptoms after unilateral chemical labyrinthectomy (UL) in rats. Levacetylleucine is promising for research of neurological manifestations of Niemann-Pick disease type C, traumatic brain injury and neurodegeneration prevention.

HY-Y0134

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid		99.93%
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid is a glutamic acid derivative.

HY-W010965

Fmoc-Glu(OAll)-OH		99.45%
Fmoc-Glu(OAll)-OH is a glutamic acid derivative.

HY-W008176

Fmoc-Lys-OH		99.93%
Fmoc-Lys-OH is a lysine derivative.

HY-I0172

L-tert-Leucine Methyl Ester Hydrochloride		≥98.0%
L-tert-Leucine Methyl Ester Hydrochloride is a leucine derivative.

HY-79128

Fmoc-L-Lys (Boc)-OH		99.98%
Fmoc-L-Lys (Boc)-OH is a lysine derivative.

HY-W013081

Fmoc-Gln(Trt)-OH		99.95%
Fmoc-Gln(Trt)-OH is a glutamine derivative containing amine protecting group Fmoc.

HY-W008016

Fmoc-Tyr(tBu)-OH		99.93%
Fmoc-Tyr(tBu)-OH is a tyrosine derivative.

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